We investigate cellular properties that underlie the ability of neuronal ensembles to extract and encode information and their experience-dependent maturation using brainstem circuits that compare information between the two ears that are critical for sound localization and may be disrupted in children with central auditory processing disorder.
We investigate the impact of RNA nucleotide modifications in RNA-protein interactions.
We investigate the inflammatory and neurodegenerative disease multiple sclerosis. Specifically, we focus on how immune signals modulate glia function to influence both pathophysiology and repair.
We investigate the molecular and biological processes governing the development of brain malignancies, including primary (e.g., glioblastoma) and metastatic (tumors originating from other locations in the body, such as breast cancer) brain cancers. Our goal is to develop novel immunotherapeutic strategies for patients with brain cancers.
We investigate the roles of the brain barriers (meninges, blood brain barrier and choroid plexus) in normal and pathological brain function. We particularly focus on immune-vascular interaction during neurodevelopment and neurodegeneration.
We investigate cells in the brain that regulate gonadotrophin-releasing hormone (GnRH) neurons, the final output cells in a large neural network controlling fertility. Our research is focused on identifying changes in these networks that underlie the development of common forms of infertility, such as polycystic ovary syndrome.
We investigate how the heart balances oxygen and nutrient delivery with its demands, aiming to understand key regulators that link oxygen supply with cardiac function. Our research focuses on identifying dysregulated mediators in disease and exploring cardioprotective mechanisms to discover therapeutic targets for cardiovascular disease.
